Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood–Brain Barrier Adherence, Uptake, and Permeation

Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D-aspartate (NMDA) receptor has been suggested as a strategy for relieving neuronal damage. The peptides NR2B9c and N-dimer have been...

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Gepubliceerd in:Pharmaceutics
Hoofdauteurs: Kristensen, Mie, Kucharz, Krzysztof, Felipe Alves Fernandes, Eduardo, Strømgaard, Kristian, Schallburg Nielsen, Morten, Cederberg Helms, Hans Christian, Bach, Anders, Ulrikkaholm Tofte-Hansen, Malte, Irene Aldana Garcia, Blanca, Lauritzen, Martin, Brodin, Birger
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408072/
https://ncbi.nlm.nih.gov/pubmed/32674358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12070661
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