Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels. To test the hypothesis that circulating EVs from AD patients can induce complement-mediated neurotoxicity involving Membrane Attack Complex (MAC)...

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Udgivet i:Cells
Main Authors: Nogueras-Ortiz, Carlos J., Mahairaki, Vasiliki, Delgado-Peraza, Francheska, Das, Debamitra, Avgerinos, Konstantinos, Eren, Erden, Hentschel, Matthew, Goetzl, Edward J., Mattson, Mark P., Kapogiannis, Dimitrios
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407141/
https://ncbi.nlm.nih.gov/pubmed/32635578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071618
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