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Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase
Aggregates of α-synuclein contribute to the etiology of Parkinson’s Disease. Protein disulfide isomerase (PDI), a chaperone and oxidoreductase, blocks the aggregation of α-synuclein. An S-nitrosylated form of PDI that cannot function as a chaperone is associated with elevated levels of aggregated α-...
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| Publicado no: | Front Cell Dev Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7406567/ https://ncbi.nlm.nih.gov/pubmed/32850841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00726 |
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