Protein disulfide isomerase does not act as an unfoldase in the disassembly of cholera toxin

Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB(5) to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced C...

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Detalles Bibliográficos
Publicado en:Biosci Rep
Main Authors: Cherubin, Patrick, Guyette, Jessica, Taylor, Michael, O’Donnell, Morgan, Herndon, Laura, Burress, Helen, Riad, Aladdin, Tatulian, Suren A., Teter, Ken
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2018
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127674/
https://ncbi.nlm.nih.gov/pubmed/30135140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181320
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