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PP2A­-B55γ counteracts Cdk1 and regulates proper spindle orientation through the cortical dynein adaptor NuMA

Proper orientation of the mitotic spindle is critical for accurate development and morphogenesis. In human cells, spindle orientation is regulated by the evolutionarily conserved protein NuMA, which interacts with dynein and enriches it at the cell cortex. Pulling forces generated by cortical dynein...

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Pubblicato in:J Cell Sci
Autori principali: Keshri, Riya, Rajeevan, Ashwathi, Kotak, Sachin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406356/
https://ncbi.nlm.nih.gov/pubmed/32591484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.243857
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