Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Mammalian transcription factor 4 (TCF4) has been linked to schizophrenia and intellectual disabilities, such as Pitt–Hopkins syndrome (PTHS). Here, we show that similarly to mammalian TCF4, fruit fly orthologue Daughterless (Da) is expressed widely in the Drosophila brain. Furthermore, silencing of...

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Библиографические подробности
Опубликовано в: :Dis Model Mech
Главные авторы: Tamberg, Laura, Jaago, Mariliis, Säälik, Kristi, Sirp, Alex, Tuvikene, Jürgen, Shubina, Anastassia, Kiir, Carl Sander, Nurm, Kaja, Sepp, Mari, Timmusk, Tõnis, Palgi, Mari
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406316/
https://ncbi.nlm.nih.gov/pubmed/32641419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.042747
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