Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Mammalian transcription factor 4 (TCF4) has been linked to schizophrenia and intellectual disabilities, such as Pitt–Hopkins syndrome (PTHS). Here, we show that similarly to mammalian TCF4, fruit fly orthologue Daughterless (Da) is expressed widely in the Drosophila brain. Furthermore, silencing of...

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Udgivet i:Dis Model Mech
Main Authors: Tamberg, Laura, Jaago, Mariliis, Säälik, Kristi, Sirp, Alex, Tuvikene, Jürgen, Shubina, Anastassia, Kiir, Carl Sander, Nurm, Kaja, Sepp, Mari, Timmusk, Tõnis, Palgi, Mari
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406316/
https://ncbi.nlm.nih.gov/pubmed/32641419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.042747
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