High–molecular weight hyaluronan attenuates tubulointerstitial scarring in kidney injury

Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition, and peritubular capillary loss. We previously showed that IL-10 stimulates high–molecular weight hyaluronan (HMW-HA) expression by fibroblasts, and we hypothesize that HMW-HA attenuates renal fibrosis by reducin...

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Udgivet i:JCI Insight
Main Authors: Wang, Xinyi, Balaji, Swathi, Steen, Emily H., Blum, Alexander J., Li, Hui, Chan, Christina K., Manson, Scott R., Lu, Thomas C., Rae, Meredith M., Austin, Paul F., Wight, Thomas N., Bollyky, Paul L., Cheng, Jizhong, Keswani, Sundeep G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406305/
https://ncbi.nlm.nih.gov/pubmed/32396531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136345
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