High–molecular weight hyaluronan attenuates tubulointerstitial scarring in kidney injury

Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition, and peritubular capillary loss. We previously showed that IL-10 stimulates high–molecular weight hyaluronan (HMW-HA) expression by fibroblasts, and we hypothesize that HMW-HA attenuates renal fibrosis by reducin...

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Publicado en:JCI Insight
Main Authors: Wang, Xinyi, Balaji, Swathi, Steen, Emily H., Blum, Alexander J., Li, Hui, Chan, Christina K., Manson, Scott R., Lu, Thomas C., Rae, Meredith M., Austin, Paul F., Wight, Thomas N., Bollyky, Paul L., Cheng, Jizhong, Keswani, Sundeep G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406305/
https://ncbi.nlm.nih.gov/pubmed/32396531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136345
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