Robust antibody and cellular responses induced by DNA-only vaccination for HIV

BACKGROUND: HVTN 098, a randomized, double-blind, placebo-controlled trial, evaluated the safety, tolerability, and immunogenicity of PENNVAX-GP HIV DNA vaccine, administered with or without plasmid IL-12 (pIL-12), via intradermal (ID) or intramuscular (IM) electroporation (EP) in healthy, HIV-uninf...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: De Rosa, Stephen C., Edupuganti, Srilatha, Huang, Yunda, Han, Xue, Elizaga, Marnie, Swann, Edith, Polakowski, Laura, Kalams, Spyros A., Keefer, Michael C., Maenza, Janine, Lu, Yiwen, Wise, Megan C., Yan, Jian, Morrow, Matthew P., Khan, Amir S., Boyer, Jean D., Humeau, Laurent, White, Scott, Pensiero, Michael, Sardesai, Niranjan Y., Bagarazzi, Mark L., Weiner, David B., Ferrari, Guido, Tomaras, Georgia D., Montefiori, David C., Corey, Lawrence, McElrath, M. Juliana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406303/
https://ncbi.nlm.nih.gov/pubmed/32437332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137079
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