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KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells
PURPOSE: The purpose of this study was to establish and analyze a cell model of Leber congenital amaurosis type 16 (LCA16), which is caused by mutations in the KCNJ13 gene encoding Kir7.1, an inward-rectifying potassium ion channel. METHODS: The two guide RNAs specific to the target sites in the KCN...
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| Udgivet i: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Association for Research in Vision and Ophthalmology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7405706/ https://ncbi.nlm.nih.gov/pubmed/32437550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.5.38 |
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