KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells

PURPOSE: The purpose of this study was to establish and analyze a cell model of Leber congenital amaurosis type 16 (LCA16), which is caused by mutations in the KCNJ13 gene encoding Kir7.1, an inward-rectifying potassium ion channel. METHODS: The two guide RNAs specific to the target sites in the KCN...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Kanzaki, Yuki, Fujita, Hirofumi, Sato, Keita, Hosokawa, Mio, Matsumae, Hiroshi, Shiraga, Fumio, Morizane, Yuki, Ohuchi, Hideyo
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2020
Subjects:
Biochemistry and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7405706/
https://ncbi.nlm.nih.gov/pubmed/32437550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.5.38
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