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Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness

Oncolytic adenoviruses (OAds) present limited efficacy in clinics. The insertion of therapeutic transgenes into OAds genomes, known as “arming OAds”, has been the main strategy to improve their therapeutic potential. Different approaches were published in the decade of the 2000s, but with few compar...

詳細記述

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書誌詳細
出版年:Int J Mol Sci
主要な著者: Farrera-Sal, Martí, de Sostoa, Jana, Nuñez-Manchón, Estela, Moreno, Rafael, Fillat, Cristina, Bazan-Peregrino, Miriam, Alemany, Ramon
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404292/
https://ncbi.nlm.nih.gov/pubmed/32708234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21145158
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