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Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses
Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic effects, preventing these viruses from reaching the clinic. Previous work h...
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| 發表在: | NAR Cancer |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8210037/ https://ncbi.nlm.nih.gov/pubmed/34316705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcab015 |
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