Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition

Activation of the nod-like receptor 3 (NLRP3) inflammasomes is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Cbl plays a pivotal role in suppressing NLRP3 inflammasome activation by inhibiting Pyk2-mediated apoptosis-assoc...

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I publikationen:Int J Mol Sci
Huvudupphovsmän: Lin, Hsin-Chung, Chen, Yu-Jen, Wei, Yau-Huei, Chuang, Yu-Ting, Hsieh, Su-Heng, Hsieh, Jing-Yu, Hsieh, Yi-Lin, Ojcius, David M., Huang, Kuo-Yang, Chung, I.-Che, Yuan, Sheng-Ning, Chang, Yu-Sun, Chen, Lih-Chyang
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404051/
https://ncbi.nlm.nih.gov/pubmed/32707731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21145104
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