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Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Pyk2 is essential for NLRP3 inflammasome activation. Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in su...

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書目詳細資料
發表在:Cell Death Dis
Main Authors: Chung, I-Che, Yuan, Sheng-Ning, OuYang, Chun-Nan, Lin, Hsin-Chung, Huang, Kuo-Yang, Chen, Yu-Jen, Chung, An-Ko, Chu, Ching-Liang, Ojcius, David M., Chang, Yu-Sun, Chen, Lih-Chyang
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208430/
https://ncbi.nlm.nih.gov/pubmed/30382081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1163-z
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