Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Pyk2 is essential for NLRP3 inflammasome activation. Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in su...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chung, I-Che, Yuan, Sheng-Ning, OuYang, Chun-Nan, Lin, Hsin-Chung, Huang, Kuo-Yang, Chen, Yu-Jen, Chung, An-Ko, Chu, Ching-Liang, Ojcius, David M., Chang, Yu-Sun, Chen, Lih-Chyang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208430/
https://ncbi.nlm.nih.gov/pubmed/30382081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1163-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados