Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Pyk2 is essential for NLRP3 inflammasome activation. Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in su...

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Publicado en:Cell Death Dis
Autores principales: Chung, I-Che, Yuan, Sheng-Ning, OuYang, Chun-Nan, Lin, Hsin-Chung, Huang, Kuo-Yang, Chen, Yu-Jen, Chung, An-Ko, Chu, Ching-Liang, Ojcius, David M., Chang, Yu-Sun, Chen, Lih-Chyang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208430/
https://ncbi.nlm.nih.gov/pubmed/30382081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1163-z
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