Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma

BACKGROUND: Cancer‐associated fibroblasts (CAFs) are among the most prominent cells during the desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC). However, CAFs are heterogeneous and the precise origins are not fully elucidated. This study aimed to explore whether monocytes can transdi...

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Veröffentlicht in:Clin Transl Med
Hauptverfasser: Huang, Xin, He, Chaobin, Hua, Xin, Kan, Anna, Mao, Yize, Sun, Shuxin, Duan, Fangting, Wang, Jun, Huang, Peng, Li, Shengping
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403727/
https://ncbi.nlm.nih.gov/pubmed/32508052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.41
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