Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury

Severed CNS axons fail to regenerate in adult mammals and there are no effective regenerative strategies to treat patients with CNS injuries. Several genes, including phosphatase and tensin homolog (PTEN) and Krüppel-like factors, regulate intrinsic growth capacity of mature neurons. The Lin28 gene...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Nathan, Fatima M., Ohtake, Yosuke, Wang, Shuo, Jiang, Xinpei, Sami, Armin, Guo, Hua, Zhou, Feng-Quan, Li, Shuxin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403348/
https://ncbi.nlm.nih.gov/pubmed/32353321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.04.010
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