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Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization

First proposed as antimicrobial agents, histones were later recognized for their role in condensing chromosomes. Histone antimicrobial activity has been reported in innate immune responses. However, how histones kill bacteria has remained elusive. The co-localization of histones with antimicrobial p...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Doolin, Tory, Amir, Henry M., Duong, Leora, Rosenzweig, Rachel, Urban, Lauren A., Bosch, Marta, Pol, Albert, Gross, Steven P., Siryaporn, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403156/
https://ncbi.nlm.nih.gov/pubmed/32753666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17699-z
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