Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

[Image: see text] The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular bacteriocin and show that pore-formation dynamics in bacterial membranes are tunable vi...

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Bibliografiset tiedot
Julkaisussa:ACS Pharmacol Transl Sci
Päätekijät: Fields, Francisco R., Manzo, Giorgia, Hind, Charlotte K., Janardhanan, Jeshina, Foik, Ilona P., Carmo Silva, Phoebe Do, Balsara, Rashna D., Clifford, Melanie, Vu, Henry M., Ross, Jessica N., Kalwajtys, Veronica R., Gonzalez, Alejandro J., Bui, Tam T., Ploplis, Victoria A., Castellino, Francis J., Siryaporn, Albert, Chang, Mayland, Sutton, J. Mark, Mason, A. James, Lee, Shaun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2020
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296547/
https://ncbi.nlm.nih.gov/pubmed/32566907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00001
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