Influence of Drug–Drug Interactions on the Pharmacokinetics of Atorvastatin and Its Major Active Metabolite ortho-OH-Atorvastatin in Aging People Living with HIV

BACKGROUND: People living with HIV (PLWH) are aging and experience age-related physiological changes and comorbidities. Atorvastatin is a widely prescribed lipid-lowering agent metabolized by cytochrome P450 (CYP) 3A4, whose hepatocyte uptake is facilitated by organic anion transporting polypeptide...

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Vydáno v:Clin Pharmacokinet
Hlavní autoři: Courlet, Perrine, Decosterd, Laurent A., Alves Saldanha, Susana, Cavassini, Matthias, Stader, Felix, Stoeckle, Marcel, Buclin, Thierry, Marzolini, Catia, Csajka, Chantal, Guidi, Monia
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
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Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403138/
https://ncbi.nlm.nih.gov/pubmed/32281059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00876-0
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