Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

T cell factor 1 (Tcf1) is the first T cell–specific protein induced by Notch signaling in the thymus, leading to the activation of two major target genes, Gata3 and Bcl11b. Tcf1 deficiency results in partial arrests in T cell development, high apoptosis, and increased development of B and myeloid ce...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Garcia-Perez, Laura, Famili, Farbod, Cordes, Martijn, Brugman, Martijn, van Eggermond, Marja, Wu, Haoyu, Chouaref, Jihed, Granado, David San León, Tiemessen, Machteld M., Pike-Overzet, Karin, Daxinger, Lucia, Staal, Frank J. T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400773/
https://ncbi.nlm.nih.gov/pubmed/32789164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7313
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