Loss of CD44(dim) Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus

Human T-cell development is less well studied than its murine counterpart due to the lack of genetic tools and the difficulty of obtaining cells and tissues. Here, we report the transcriptional landscape of 11 immature, consecutive human T-cell developmental stages. The changes in gene expression of...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Canté-Barrett, Kirsten, Mendes, Rui D., Li, Yunlei, Vroegindeweij, Eric, Pike-Overzet, Karin, Wabeke, Tamara, Langerak, Anton W., Pieters, Rob, Staal, Frank J. T., Meijerink, Jules P. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247458/
https://ncbi.nlm.nih.gov/pubmed/28163708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00032
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