Monopolar Spindle 1 Kinase (MPS1/TTK) mRNA Expression is Associated with Earlier Development of Clinical Symptoms, Tumor Aggressiveness and Survival of Glioma Patients

Inhibition of the protein kinase MPS1, a mitotic spindle-checkpoint regulator, reinforces the effects of multiple therapies against glioblastoma multiforme (GBM) in experimental settings. We analyzed MPS1 mRNA-expression in gliomas WHO grade II, III and in clinical subgroups of GBM. Data were obtain...

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Published in:Biomedicines
Main Authors: Kessler, Almuth F., Feldheim, Jonas, Schmitt, Dominik, Feldheim, Julia J., Monoranu, Camelia M., Ernestus, Ralf-Ingo, Löhr, Mario, Hagemann, Carsten
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399822/
https://ncbi.nlm.nih.gov/pubmed/32635204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8070192
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