DNB-based on-chip motif finding: A high-throughput method to profile different types of protein-DNA interactions

Here, we report a sensitive DocMF system that uses next-generation sequencing chips to profile protein-DNA interactions. Using DocMF, we successfully identified a variety of endonuclease recognition sites and the protospacer adjacent motif (PAM) sequences of different CRISPR systems. DocMF can simul...

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Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Li, Zhuokun, Wang, Xiaojue, Xu, Dongyang, Zhang, Dengwei, Wang, Dan, Dai, Xuechen, Wang, Qi, Li, Zhou, Gu, Ying, Ouyang, Wenjie, Zhao, Shuchang, Huang, Baoqian, Gong, Jian, Zhao, Jing, Chen, Ao, Shen, Yue, Dong, Yuliang, Zhang, Wenwei, Xu, Xun, Xu, Chongjun, Jiang, Yuan
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2020
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399529/
https://ncbi.nlm.nih.gov/pubmed/32789179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb3350
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