Reliable multiplex sequencing with rare index mis-assignment on DNB-based NGS platform

BACKGROUND: Massively-parallel-sequencing, coupled with sample multiplexing, has made genetic tests broadly affordable. However, intractable index mis-assignments (commonly exceeds 1%) were repeatedly reported on some widely used sequencing platforms. RESULTS: Here, we investigated this quality issu...

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Veröffentlicht in:BMC Genomics
Hauptverfasser: Li, Qiaoling, Zhao, Xia, Zhang, Wenwei, Wang, Lin, Wang, Jingjing, Xu, Dongyang, Mei, Zhiying, Liu, Qiang, Du, Shiyi, Li, Zhanqing, Liang, Xinming, Wang, Xiaman, Wei, Hanmin, Liu, Pengjuan, Zou, Jing, Shen, Hanjie, Chen, Ao, Drmanac, Snezana, Liu, Jia Sophie, Li, Li, Jiang, Hui, Zhang, Yongwei, Wang, Jian, Yang, Huanming, Xu, Xun, Drmanac, Radoje, Jiang, Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416933/
https://ncbi.nlm.nih.gov/pubmed/30866797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-5569-5
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