Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD

CRAF activation requires binding to membrane-anchored and active GTP-bound RAS. Whereas its RAS-binding domain (RBD) contains the main binding interface to the RAS G domain, its cysteine-rich domain (CRD) is responsible for association to anionic lipid-rich membranes. Both RAF domains are connected...

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Publicado no:Biophys J
Main Authors: Travers, Timothy, López, Cesar A., Agamasu, Constance, Hettige, Jeevapani J., Messing, Simon, García, Angel E., Stephen, Andrew G., Gnanakaran, S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399501/
https://ncbi.nlm.nih.gov/pubmed/32649863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.06.021
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