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A “Tug of War” Maintains a Dynamic Protein–Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane

[Image: see text] Association of Raf kinase with activated Ras triggers downstream signaling cascades toward regulating transcription in the cells’ nucleus. Dysregulation of Ras–Raf signaling stimulates cancers. We investigate the C-Raf RBD and CRD regions when bound to oncogenic K-Ras4B at the memb...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Li, Zhen-Lu, Prakash, Priyanka, Buck, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832993/
https://ncbi.nlm.nih.gov/pubmed/29532030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00593
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