A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block P. vivax parasite transition from liver stage infection to blood stage infection. Human liver-chimer...

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Publicat a:iScience
Autors principals: Schäfer, Carola, Roobsoong, Wanlapa, Kangwanrangsan, Niwat, Bardelli, Martino, Rawlinson, Thomas A., Dambrauskas, Nicholas, Trakhimets, Olesya, Parthiban, Chaitra, Goswami, Debashree, Reynolds, Laura M., Kennedy, Spencer Y., Flannery, Erika L., Murphy, Sean C., Sather, D. Noah, Draper, Simon J., Sattabongkot, Jetsumon, Mikolajczak, Sebastian A., Kappe, Stefan H.I.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399188/
https://ncbi.nlm.nih.gov/pubmed/32739836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101381
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