A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block P. vivax parasite transition from liver stage infection to blood stage infection. Human liver-chimer...

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Bibliographic Details
Published in:iScience
Main Authors: Schäfer, Carola, Roobsoong, Wanlapa, Kangwanrangsan, Niwat, Bardelli, Martino, Rawlinson, Thomas A., Dambrauskas, Nicholas, Trakhimets, Olesya, Parthiban, Chaitra, Goswami, Debashree, Reynolds, Laura M., Kennedy, Spencer Y., Flannery, Erika L., Murphy, Sean C., Sather, D. Noah, Draper, Simon J., Sattabongkot, Jetsumon, Mikolajczak, Sebastian A., Kappe, Stefan H.I.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399188/
https://ncbi.nlm.nih.gov/pubmed/32739836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101381
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