Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism

CDC-like kinase 3 (CLK3) is a dual specificity kinase that functions on substrates containing serine/threonine and tyrosine. But its role in human cancer remains unknown. Herein, we demonstrated that CLK3 was significantly up-regulated in cholangiocarcinoma (CCA) and identified a recurrent Q607R som...

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Publicado no:J Exp Med
Main Authors: Zhou, Qingxin, Lin, Meihua, Feng, Xing, Ma, Fei, Zhu, Yuekun, Liu, Xing, Qu, Chao, Sui, Hong, Sun, Bei, Zhu, Anlong, Zhang, Heng, Huang, He, Gao, Zhi, Zhao, Yongxiang, Sun, Jiangyun, Bai, Yuxian, Jin, Junfei, Hong, Xuehui, Zou, Chang, Zhang, Zhiyong
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398168/
https://ncbi.nlm.nih.gov/pubmed/32453420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191779
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