Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner

BACKGROUND: Aggravated liver ischemia and reperfusion (IR) injury has been reported in aged mice. Although necroptosis inhibition showed no crucial effect on hepatic IR injury in young mice, whether and how necroptosis affects liver IR injury in aged mice remains unclear. METHODS: Young and aged mic...

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Publicado en:Ann Transl Med
Main Authors: Zhong, Weizhe, Wang, Xiaowei, Rao, Zhuqing, Pan, Xiongxiong, Sun, Yu, Jiang, Tao, Wang, Ping, Zhou, Haoming, Wang, Xuehao
Formato: Artigo
Idioma:Inglês
Publicado: AME Publishing Company 2020
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396804/
https://ncbi.nlm.nih.gov/pubmed/32793713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm-20-2822
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