Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver-Resident Macrophage M2 Polarization via C/EBP Homologous Protein-Mediated Endoplasmic Reticulum Stress

Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. Liver-resident macrophages (Kupffer cells, KCs) and endoplasmic reticulum (ER) stress play crucial roles in the pathogenesis of liver IR injury. In this stu...

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Publicado no:Front Immunol
Main Authors: Rao, Zhuqing, Sun, Jie, Pan, Xiongxiong, Chen, Ziyang, Sun, Heliang, Zhang, Panpan, Gao, Mei, Ding, Zhengnian, Liu, Cunming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645540/
https://ncbi.nlm.nih.gov/pubmed/29081777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01299
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