Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner

BACKGROUND: Aggravated liver ischemia and reperfusion (IR) injury has been reported in aged mice. Although necroptosis inhibition showed no crucial effect on hepatic IR injury in young mice, whether and how necroptosis affects liver IR injury in aged mice remains unclear. METHODS: Young and aged mic...

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Gepubliceerd in:Ann Transl Med
Hoofdauteurs: Zhong, Weizhe, Wang, Xiaowei, Rao, Zhuqing, Pan, Xiongxiong, Sun, Yu, Jiang, Tao, Wang, Ping, Zhou, Haoming, Wang, Xuehao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AME Publishing Company 2020
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396804/
https://ncbi.nlm.nih.gov/pubmed/32793713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm-20-2822
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