Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and in vitro characterization of C1qNb75, a single domain antibody (na...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Laursen, Nick S., Pedersen, Dennis V., Gytz, Heidi, Zarantonello, Alessandra, Bernth Jensen, Jens Magnus, Hansen, Annette G., Thiel, Steffen, Andersen, Gregers R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396675/
https://ncbi.nlm.nih.gov/pubmed/32849513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01504
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