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Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and in vitro characterization of C1qNb75, a single domain antibody (na...
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| Izdano u: | Front Immunol |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7396675/ https://ncbi.nlm.nih.gov/pubmed/32849513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01504 |
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