Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

Children show a higher incidence of leukemia compared to young adolescents, yet their cells have less age-related (oncogenic) somatic mutations. Newborns with Down syndrome have an even higher risk of developing leukemia, which is thought to be driven by mutations that accumulate during fetal develo...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Hasaart, Karlijn A. L., Manders, Freek, van der Hoorn, Marie-Louise, Verheul, Mark, Poplonski, Tomasz, Kuijk, Ewart, de Sousa Lopes, Susana M. Chuva, van Boxtel, Ruben
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395765/
https://ncbi.nlm.nih.gov/pubmed/32737409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69822-1
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