FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

BACKGROUND: Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage. Lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expressed on the surface of lymphatic endothel...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Shrestha, Shikshya, Cho, Woohyun, Stump, Benjamin, Imani, Jewel, Lamattina, Anthony M., Louis, Pierce H., Pazzanese, James, Rosas, Ivan O., Visner, Gary, Perrella, Mark A., El-Chemaly, Souheil
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395348/
https://ncbi.nlm.nih.gov/pubmed/32736525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00204-z
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