FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

BACKGROUND: Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage. Lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expressed on the surface of lymphatic endothel...

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Dades bibliogràfiques
Publicat a:Mol Med
Autors principals: Shrestha, Shikshya, Cho, Woohyun, Stump, Benjamin, Imani, Jewel, Lamattina, Anthony M., Louis, Pierce H., Pazzanese, James, Rosas, Ivan O., Visner, Gary, Perrella, Mark A., El-Chemaly, Souheil
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395348/
https://ncbi.nlm.nih.gov/pubmed/32736525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00204-z
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