Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity da...

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Vydáno v:Arch Toxicol
Hlavní autoři: Shi, Miaoying, Bouwmeester, Hans, Rietjens, Ivonne M. C. M., Strikwold, Marije
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
Témata:
Organ Toxicity and Mechanisms
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395048/
https://ncbi.nlm.nih.gov/pubmed/32367273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02766-7
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