Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data

Physiologically based kinetic (PBK) modelling-based reverse dosimetry is a promising tool for the prediction of in vivo developmental toxicity using in vitro concentration–response data. In the present study, the potential of this approach to predict the dose-dependent increase of uterus weight in r...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Arch Toxicol
Hlavní autoři: Zhang, Mengying, van Ravenzwaay, Bennard, Fabian, Eric, Rietjens, Ivonne M. C. M., Louisse, Jochem
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2017
Témata:
Toxicokinetics and Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866837/
https://ncbi.nlm.nih.gov/pubmed/29234833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2140-5
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky