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Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data

Physiologically based kinetic (PBK) modelling-based reverse dosimetry is a promising tool for the prediction of in vivo developmental toxicity using in vitro concentration–response data. In the present study, the potential of this approach to predict the dose-dependent increase of uterus weight in r...

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Dades bibliogràfiques
Publicat a:Arch Toxicol
Autors principals: Zhang, Mengying, van Ravenzwaay, Bennard, Fabian, Eric, Rietjens, Ivonne M. C. M., Louisse, Jochem
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866837/
https://ncbi.nlm.nih.gov/pubmed/29234833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2140-5
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