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Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca(2+) in the cytoplasm of C2C12 myoblasts and HCT116 carcinoma cells. We also ob...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7394923/ https://ncbi.nlm.nih.gov/pubmed/32738613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101370 |
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