A Temperature-Dependent Translation Defect Caused by Internal Ribosome Entry Site Mutation Attenuates Foot-and-Mouth Disease Virus: Implications for Rational Vaccine Design

Foot-and-mouth disease (FMD), which is caused by FMD virus (FMDV), remains a major plague among cloven-hoofed animals worldwide, and its outbreak often has disastrous socioeconomic consequences. A live-attenuated FMDV vaccine will greatly facilitate the global control and eradication of FMD, but a s...

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Bibliographic Details
Published in:	J Virol
Main Authors:	Yang, Decheng, Sun, Chao, Gao, Rongyuan, Wang, Haiwei, Liu, Wenming, Yu, Kewei, Zhou, Guohui, Zhao, Bo, Yu, Li
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2020
Subjects:	Vaccines and Antiviral Agents
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7394902/ https://ncbi.nlm.nih.gov/pubmed/32493820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00990-20
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A Temperature-Dependent Translation Defect Caused by Internal Ribosome Entry Site Mutation Attenuates Foot-and-Mouth Disease Virus: Implications for Rational Vaccine Design

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