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A Temperature-Dependent Translation Defect Caused by Internal Ribosome Entry Site Mutation Attenuates Foot-and-Mouth Disease Virus: Implications for Rational Vaccine Design

Foot-and-mouth disease (FMD), which is caused by FMD virus (FMDV), remains a major plague among cloven-hoofed animals worldwide, and its outbreak often has disastrous socioeconomic consequences. A live-attenuated FMDV vaccine will greatly facilitate the global control and eradication of FMD, but a s...

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Podrobná bibliografie
Vydáno v:J Virol
Hlavní autoři: Yang, Decheng, Sun, Chao, Gao, Rongyuan, Wang, Haiwei, Liu, Wenming, Yu, Kewei, Zhou, Guohui, Zhao, Bo, Yu, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394902/
https://ncbi.nlm.nih.gov/pubmed/32493820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00990-20
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