Obesity of G2e3 Knockout Mice Suggests That Obesity-Associated Variants Near Human G2E3 Decrease G2E3 Activity

PURPOSE: In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links inactivation of either gene to changes in body fa...

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Publicado en:Diabetes Metab Syndr Obes
Autores principales: Powell, David R, Doree, Deon D, DaCosta, Christopher M, Platt, Kenneth A, Hansen, Gwenn M, van Sligtenhorst, Isaac, Ding, Zhi-Ming, Revelli, Jean-Pierre, Brommage, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2020
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394505/
https://ncbi.nlm.nih.gov/pubmed/32801815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S259546
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