Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors

BACKGROUND: Pyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens. Pyrazinamide-susceptibility test usually takes a week to have a diagnosis to guide initial therapy, implying a delay in receiving appropriate therapy....

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Veröffentlicht in:PLoS One
Hauptverfasser: Supo-Escalante, Rydberg Roman, Médico, Aldhair, Gushiken, Eduardo, Olivos-Ramírez, Gustavo E., Quispe, Yaneth, Torres, Fiorella, Zamudio, Melissa, Antiparra, Ricardo, Amzel, L. Mario, Gilman, Robert H., Sheen, Patricia, Zimic, Mirko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394417/
https://ncbi.nlm.nih.gov/pubmed/32735615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235643
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