MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

The connections between energy metabolism and stemness of hematopoietic stem cells (HSCs) at different developmental stages remain largely unknown. We generated a transgenic mouse line for the genetically encoded NADH/NAD(+) sensor (SoNar) and demonstrate that there are 3 distinct fetal liver hemato...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Gu, Hao, Chen, Chiqi, Hao, Xiaoxin, Su, Ni, Huang, Dan, Zou, Yejun, Lin, Shu-Hai, Chen, Xianjun, Zheng, Denghao, Liu, Ligen, Yu, Zhuo, Xie, Li, Zhang, Yaping, He, Xiaoxiao, Lai, Xiaoyun, Zhang, Xiaocui, Chen, Guo-Qiang, Zhao, Yuzheng, Yang, Yi, Loscalzo, Joseph, Zheng, Junke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393259/
https://ncbi.nlm.nih.gov/pubmed/32396938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003940
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