MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

The connections between energy metabolism and stemness of hematopoietic stem cells (HSCs) at different developmental stages remain largely unknown. We generated a transgenic mouse line for the genetically encoded NADH/NAD(+) sensor (SoNar) and demonstrate that there are 3 distinct fetal liver hemato...

Full description

Saved in:
Bibliographic Details
Published in:Blood
Main Authors: Gu, Hao, Chen, Chiqi, Hao, Xiaoxin, Su, Ni, Huang, Dan, Zou, Yejun, Lin, Shu-Hai, Chen, Xianjun, Zheng, Denghao, Liu, Ligen, Yu, Zhuo, Xie, Li, Zhang, Yaping, He, Xiaoxiao, Lai, Xiaoyun, Zhang, Xiaocui, Chen, Guo-Qiang, Zhao, Yuzheng, Yang, Yi, Loscalzo, Joseph, Zheng, Junke
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393259/
https://ncbi.nlm.nih.gov/pubmed/32396938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003940
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items