SIRT3-dependent GOT2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth

The malate–aspartate shuttle is indispensable for the net transfer of cytosolic NADH into mitochondria to maintain a high rate of glycolysis and to support rapid tumor cell growth. The malate–aspartate shuttle is operated by two pairs of enzymes that localize to the mitochondria and cytoplasm, gluta...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Yang, Hui, Zhou, Lisha, Shi, Qian, Zhao, Yuzheng, Lin, Huaipeng, Zhang, Mengli, Zhao, Shimin, Yang, Yi, Ling, Zhi-Qiang, Guan, Kun-Liang, Xiong, Yue, Ye, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406655/
https://ncbi.nlm.nih.gov/pubmed/25755250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591041
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