STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to aerobic glycolysis in tumour cells. However,...

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Vydáno v:Nat Commun
Hlavní autoři: Balic, Jesse J., Albargy, Hassan, Luu, Kevin, Kirby, Francis J., Jayasekara, W. Samantha N., Mansell, Finbar, Garama, Daniel J., De Nardo, Dominic, Baschuk, Nikola, Louis, Cynthia, Humphries, Fiachra, Fitzgerald, Katherine, Latz, Eicke, Gough, Daniel J., Mansell, Ashley
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393113/
https://ncbi.nlm.nih.gov/pubmed/32732870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17669-5
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